Chronic Nicotine Intake Retards Age-Related Motor Skill Deterioration
A groundbreaking study, titled "Nicotine Reprograms Aging-Related Metabolism and Protects Against Motor Decline in Mice", has been published in the prestigious journal Advanced Science. Led by Professor LIU Xin'an and his team, the research evaluates the impact of long-term nicotine exposure on aging populations, focusing particularly on motor decline and metabolic health.
The study, which is open access, observed attenuated motor decline in nicotine-treated mice without significant alterations in major metabolism-related peripheral organs or immune system dysfunction. The team found that nicotine regulates sphingolipid turnover to enhance nicotinamide adenine dinucleotide (NAD+) availability and energy metabolism, which correlated with reduced ceramide accumulation and improved motor function.
Mice were permitted to orally consume nicotine over a 22-month period as part of the study. Dynamic gut microbiota profiling revealed that nicotine consumption preserved microbiota composition and altered microbial-derived metabolites associated with the sphingolipid pathway. The BMAge score, a biomarker of aging, confirmed a biologically younger phenotype in the nicotine-treated mice.
The research team, with expertise in metabolism, neurobiology, and inhalable materials, also identified nicotine-responsive pathways related to glycolipid metabolism and energy homeostasis. The next research fields of the group led by Prof. LIU Xin'an and Prof. CHEN Zuxin in studying nicotine's effects on aging focus on how nicotine reprograms aging-related metabolism and protects against motor decline.
This study offers promising insights into the potential benefits of nicotine in slowing motor decline and improving metabolic health in aging populations. However, it is important to note that further research is needed to fully understand the implications of these findings and to ensure their safety and efficacy for human health.
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