Revolutionary Medication Invigorates Sluggish Hair Roots: Potential Game-Changer in Halting Hair Loss, Claim Experts.
In a breakthrough for those suffering from hair loss, a new drug called PP405 has been developed. This groundbreaking agent, developed by biotech company FollicleRx, reactivates dormant hair follicle cells, triggering new hair growth.
The development of PP405 was aided by the work of Heather Christofk, Ph.D., a biochemist at UCLA, and William Lowry, Ph.D., a stem cell biologist at UCLA. The mechanism of PP405 involves boosting the body's natural availability of lactate, which directly affects the follicles' ability to grow hair.
Researchers discovered a way to wake up dormant hair follicle stem cells by increasing lactate levels in them. Mice experiments showed that low lactate levels in hair-follicle stem cells can lead to baldness, while increasing lactate levels can speed up hair growth.
PP405 differs from current treatments like minoxidil and finasteride, which only slow down hair loss. It is also unique in that its action is confined to the scalp.
The drug has gone through two clinical trials to test safety and has shown promising results. The effectiveness of PP405 is planned to be tested in a trial next year.
PP405 is better at inhibiting the protein that moves pyruvate into mitochondria compared to UK-5099, increasing its potential efficacy. Additionally, PP405's instability in the blood means it is unlikely to cause side effects.
The research on PP405 was published in the journal "Nature Cell Biology". The researchers, led by Christofk, are currently seeking alternative sources of funding due to federal funding cuts.
Pelage Pharmaceuticals, founded by Lowry, Christofk, and Jung, is continuing research on PP405 with the aim of bringing it to market. This new drug may be useful for people suffering from different types of hair loss, such as chemotherapy-induced hair loss.
Connie Chang, a freelance writer in the Bay Area, covers science, parenting, and health. She writes about this latest development, highlighting the potential impact PP405 could have on those struggling with hair loss. As a recovering scientist, inveterate knitter, and fan fiction enthusiast, Chang brings a unique perspective to her writing.
It's important to note that hair follicles go through phases of activity and rest, governed by hair-follicle stem cells. During periods of rest, hair stops growing and eventually falls out. With PP405, there is hope that dormant hair follicle cells can be reactivated, leading to new hair growth.
Stay tuned for updates on the effectiveness trial of PP405, set to begin next year. This promising new drug could revolutionise the treatment of hair loss.
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