Week 1 NFL Predictions, Odds, Top Picks by a Reliable Computer Model: A Potential 5-team Football Parlay Could Yield 25-1 Returns

The NFL season is upon us, and the 2025 campaign promises to be an exciting one. The Dallas Cowboys and Philadelphia Eagles will clash in the NFL Kickoff Game, a highly anticipated matchup that is sure to set the tone for the season.

The Eagles are favourites for the encounter, with a spread of -7.5, reflecting their strong form in the 2024 season. On the other hand, the Cowboys are looking to bounce back after a disappointing campaign that saw them miss out on the playoffs.

In the AFC, the Cincinnati Bengals will open their season against the Cleveland Browns. Bengals quarterback Joe Burrow had a near-MVP year in 2024, but he has a record of 3-5 against the Browns in his career. The Bengals are 5.5-point favourites for the game, suggesting that the oddsmakers are confident in Burrow's ability to turn things around.

Meanwhile, the Washington Commanders are in high spirits after reaching the NFC Championship Game last season. Terry McLaurin has a new contract and is expected to be in the lineup for the Commanders' opener. Jayden Daniels had a dominant 2024 season, completing 69% of his passes for 3,568 yards, 25 touchdowns, and just nine interceptions. The Commanders are favoured to cover against the New York Giants (-6, 45.5).

Interestingly, a computer model that simulates every NFL game 10,000 times has made five confident NFL best bets for Week 1 of the 2025 season. The model's Week 1 NFL best bets and NFL parlay can be found on the model's website. The model also made four other NFL matchup picks where it says the line is way off.

The Cleveland Browns have named Joe Flacco as their Week 1 starter for the 2025 season. The Commanders won both meetings against the Giants last season, and they will be looking to carry that form into the new season.

The Philadelphia Eagles faced the Dallas Cowboys in the NFC East during the NFL season opener on September 4, 2025, with significant fan and team expectations. The Cowboys had traded Micah Parsons to the Green Bay Packers, and the Eagles were seen as the team engaging in value creation for NFL betting.

The Washington Commanders reached the NFC Championship Game last season, but they will face a tough test in their opener against the Giants. The Bengals, despite their disappointing end to the 2024 season, will be eager to make amends against the Browns.

As the NFL season gets underway, fans and bettors alike will have their eyes on these exciting matchups. With the new season comes new opportunities, and it will be interesting to see how these teams perform in the opening week. Stay tuned for more NFL news and analysis as the season unfolds.

Week 1 NFL Predictions, Odds, Top Picks by a Reliable Computer Model: A Potential 5-team Football Parlay Could Yield 25-1 Returns